Home/Quiz/Acinic Cell Carcinoma MCQs Quiz Acinic Cell Carcinoma MCQs Quiz Welcome to your Acinic Cell Carcinoma MCQs Quiz 1. None 2. A 50-year-old female presents with a slow-growing, painless swelling in the inferior pole of the parotid gland. Clinical examination reveals a firm, well-defined mass without any facial nerve involvement. Fine-needle aspiration cytology (FNAC) suggests the presence of serous acinar-like cells with granular, basophilic cytoplasm. Which of the following is the most likely diagnosis? Pleomorphic adenoma Acinic cell carcinoma (ACC) Adenoid cystic carcinoma Mucoepidermoid carcinoma None 3. A 45-year-old male with a history of parotid gland tumor resection 5 years ago presents with recurrent swelling in the same area. Imaging reveals a 2.5 cm mass in the superficial lobe of the parotid gland. Which of the following factors makes recurrence likely in acinic cell carcinoma? Presence of oncocytic cells Downregulation of PTEN and Apc genes Low mitotic activity High degree of pleomorphism None 4. A 60-year-old female presents with a slow-growing mass in the buccal mucosa. Biopsy shows tumor cells forming solid sheets with basophilic granular cytoplasm. Which of the following is the most common site for ACC outside the major salivary glands? Palate Lips Buccal mucosa Floor of the mouth None 5. A 52-year-old patient presents with a slowly enlarging, painless swelling in the lower pole of the parotid gland. MRI shows a well-circumscribed tumor without invasion. Which of the following histological patterns is most likely seen in this tumor? Solid growth pattern with fine fibrovascular septae Cribiform pattern with perineural invasion Mucous-producing cells in cystic spaces High mitotic rate and necrosis None 6. A 55-year-old male presents with a painless parotid gland swelling. A biopsy reveals tumor cells forming large cystic spaces lined by cuboidal epithelium with papillary projections. Which histologic subtype of ACC does this represent? Microcystic pattern Solid pattern Papillary cystic pattern Follicular pattern None 7. A 48-year-old woman presents with a slow-growing, painless parotid mass. A total parotidectomy is performed. Histopathology reveals PAS-positive and diastase-resistant cytoplasmic granules. What do these histological findings suggest? Secretory carcinoma Pleomorphic adenoma Acinic cell carcinoma Adenoid cystic carcinoma None 8. Which of the following is a poor prognostic factor for ACC? Occurrence in the minor salivary glands Tumor size less than 3 cm Presence of distant metastasis Low mitotic index None 9. A patient undergoes a lobectomy for a superficial parotid tumor. Post-surgical biopsy confirms acinic cell carcinoma. What is the most appropriate next step? Chemotherapy Radiotherapy Observation and follow-up Immediate re-surgery None 10. Which of the following genetic alterations is associated with acinic cell carcinoma? Which of the following genetic alterations is associated with acinic cell carcinoma? p53 overexpression PTEN downregulation and mTOR upregulation BRAF mutation None 11. A patient with ACC presents with lung metastases. What is the most appropriate management? Surgical removal of the metastases Radiotherapy to the lung Palliative chemotherapy Immunotherapy None 1 out of 6 Time's up
