Why Does Hair Fall Increase Initially After PRP, Exosomes, or Minoxidil Spray? What You Should Know

Introduction

Many people panic when they notice increased hair fall shortly after beginning PRP therapy, Exosome treatments, or Minoxidil spray. But here’s the good news — this is actually a sign of new growth activity, not failure. In this article, Medsterz experts explain why this happens, what’s going on beneath the scalp, and how to manage it effectively.

1. The Science Behind Hair Shedding

Each hair follicle cycles through three main stages:

• Anagen (growth phase)

• Catagen (transition phase)

• Telogen (resting/shedding phase)

When you start treatments like PRP, Exosomes, or Minoxidil, dormant follicles are reactivated. Old, weak hairs are pushed out to make room for new, thicker hair shafts — leading to temporary increased shedding.

📊 Scientific Evidence:

• A 2019 study in the Journal of Cosmetic Dermatology showed that Minoxidil initially causes increased telogen shedding before new anagen hair growth begins.

• A 2021 review in Aesthetic Plastic Surgery confirmed that PRP and Exosome therapy accelerate follicle turnover and regeneration, which can temporarily increase shedding during early cycles.

2. Duration of the Shedding Phase

Typically, this shedding lasts about 2–6 weeks after starting therapy.

• With PRP or Exosomes, shedding may appear 10–20 days post-procedure.

• With Minoxidil, it usually starts around 2–4 weeks after initiation.

By the third month, shedding reduces significantly, and visible regrowth begins.

3. How to Manage the Shedding Phase

Here’s how you can manage and minimize worry during this period:
✅ Stay consistent: Do not stop your treatment mid-way; this disrupts the regrowth cycle.
✅ Use mild shampoos: Avoid harsh chemicals that can worsen breakage.
✅ Add supplements: Biotin, Vitamin D, Zinc, and Omega-3s can support new hair strength.
✅ Gentle scalp massage: Improves blood circulation and helps absorb growth factors.

4. When to Worry

While mild shedding is normal, you should consult your dermatologist if:

• Shedding continues beyond 2 months.

• You develop itching, redness, or inflammation on the scalp.

• You experience patchy bald spots instead of uniform shedding.

5. Long-Term Outlook

After this temporary phase, patients usually notice:

• Thicker hair shafts

• Improved density

• Visible regrowth within 3–4 months
  Consistency is key — the initial hair fall is a sign that your follicles are responding to the treatment.

Conclusion

The initial shedding after PRP, Exosome therapy, or Minoxidil isn’t hair loss — it’s hair renewal. Stay consistent, follow aftercare instructions, and be patient. Within months, the results will speak for themselves.